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As of my last update in January 2022, Tucaxen (tucatinib) is a medication used in the treatment of HER2-positive breast cancer, particularly in cases where the cancer has metastasized or spread to other parts of the body. While Tucaxen is generally well-tolerated by many patients, there are specific populations for whom its use may be contraindicated or require special consideration.

Hypersensitivity: Individuals with a known hypersensitivity or allergic reaction to Tucaxen 150 mg (Tucatinib) or any of the other ingredients in Tucaxen should not take the medication. Allergic reactions can range from mild skin rashes to severe anaphylaxis and require immediate medical attention.

Severe Hepatic Impairment: Tucaxen is primarily metabolized in the liver, so patients with severe hepatic impairment may have difficulty metabolizing the drug, leading to potential toxicity. Therefore, Tucaxen is contraindicated in patients with severe liver dysfunction.

Pregnancy and Breastfeeding: Tucaxen has the potential to cause harm to a developing fetus, based on animal studies. Therefore, it is not recommended for use during pregnancy unless the potential benefits outweigh the risks to the fetus. Additionally, breastfeeding is not recommended during treatment with Tucaxen due to the potential for harm to the nursing infant.



Drug Interactions: Tucaxen may interact with other medications, potentially altering their effectiveness or increasing the risk of adverse effects. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting treatment with Tucaxen to avoid potentially harmful interactions.

Pediatric Population: The safety and efficacy of Tucaxen in pediatric patients have not been established, so its use in this population is generally not recommended.

It's important for healthcare providers to carefully evaluate the individual patient's medical history, concurrent medications, and potential risk factors before prescribing Tucaxen. Patients should also discuss any concerns or questions they have about the medication with their healthcare provider before starting treatment.

As of my last update in January 2022, Tucaxen (tucatinib) is a medication used in the treatment of HER2-positive breast cancer, particularly in cases where the cancer has metastasized or spread to other parts of the body. While Tucaxen is generally well-tolerated by many patients, there are specific populations for whom its use may be contraindicated or require special consideration.
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